Anabolic steroids: trenbolone, stanozolol, primobolan

A major specialist in the development and introduction of new drugs, a scientist-pharmacologist who has more than 10 years of research in the field of steroid use, Seth Roberts, in a number of his works spoke about the effect of steroids on the human body.

Effect of Trenbolone

Thus, the derivative of nandrolone – trenbolone, does not have a methyl group, being in position 19. It has a great ability to strongly bind not only to progesterone receptors, but also to androgenic ones. Most likely, such strong links affect the fact that trenbolone acts as an antagonist to the receptor of progesterone. As a rule, it is commonly believed that gynecomastia is caused by antagonists of progestinone. Indeed, studies confirm that trenbolone is the cause of a decrease in the body’s level of estrogen receptors. In addition, this strong link directly causes the person taking this medication to feel a decrease in their libido, and in some cases even lose it. And this applies to almost all adherents of the drug.

Free on the market, this androgen is not metabolized in skeletal muscles to the level of 3-alpha metabolites. As a result, there is a rapid and noticeable increase in the size and strength level.

Experiments carried out on live animals have yielded results that suggest that trenbolone is the cause of the appearance of antiglucocorticoid effects. At the same time, there is no evidence that this drug can have exactly the same effect on the human body. Can not be trenbolone converted to estrogen. While the prevailing opinion about the impossibility of reducing trenbolone by 5-alpha, some scientists in their scientific papers prove that this steroid shows much less activity in those tissues in which a large amount of 5-alpha reductase is contained.

Exactly the same effect occurs with nandrolone. And, given that the trenbolone simultaneously represents a 19-norsteroid, there is every reason to assert that it, in fact, is reduced to weaker metabolites. This explains the occurrence of gynecomastia, cases when the body stopped producing testosterone, despite the fact that estrogen can not be converted from trenbolone. The androgen-estrogen balance is disturbed by a decrease in androgenic stimulation due to the production of not so potent 5-alpha-reduced androgens. All this is the reason for the increased content of estrogen signals in the hypothalamus.

The main problem with the use of trenbolone can be considered that it is almost impossible to get this drug, made directly for human consumption. This drug is called parabolan, but it is almost completely inaccessible for consumption. In addition, now the black market in all trade trenbolanom, which is intended for consumption by cattle. This drug is called Finaplix and in clandestine laboratories this steroid is converted into an injectable liquid. This is done by dissolving ippenant pellets in the solvent, and then the resulting mixture is boiled. As a result, the drug can be injected into the body. In addition, it is not a big problem to self-spill all the necessary equipment for its production and without much effort to get pellets from pellets at home. However, one must always remember the problem of sterility of such underground production. Increased risk of infection, sepsis, abscess. It is not excluded even the possibility of getting an anaphylactic shock, and this is a direct threat of death. In addition, it must be remembered that those solvents pellets that are used to produce the injectable mixture are not intended for this purpose, therefore the risk of poisoning, respectively, increases.

Now, trenbolone is available for consumption in the form of enanthate, acetate or ether of hexahydrobenzylcarbonate. The latter is taken either every day, or with one-day interruptions. Previously, it was a product for use in veterinary medicine and it was called Finadzhekt. However, this drug is not currently available. However, clandestine laboratories produce enanthate ether, which can be consumed no more than once a week. But even in this case, his active supporters, as a rule, take this drug much more often. Not very long was the age of the ether of hexahydrobenzylcarbonate. Initially produced under the name Parabolan and intended specifically for human use, it lasted for a very short time on the market. This has become a kind of signal for clandestine producers, who constantly release similar analogues of enanthate ether. Such drugs have an even shorter age, are also injected, once a week or ten days, and sometimes every two weeks. Together with other steroids, trenbolone, which is a potent enough anabolic, can significantly increase both weight and strength. But, in addition to pronounced anabolic properties, trenbolone also has such side effects as the appearance of acne, hair loss, an increase in blood pressure, and especially this drug has a negative effect on the kidneys and urogenital system. For the sake of justice it is necessary to recognize that this influence does not have its confirmation in the scientific literature by conducting appropriate scientific experiments, but it is known that the work of the kidneys is affected by androgenic stimulation. Trenbolone, however, causing hypertension, thus quite badly harms the kidneys. Therefore, this steroid should be taken with extreme caution.

The influence of Primobolan

Under the name Primobolan, a synthetic derivative of dihydrotestosterone, the methenolone, is on the market. This is one type of acetate acetate, which must be ingested orally. However, earlier versions of this drug existed that allowed injections. According to many, Primobolan is an absolutely ineffective drug, therefore this steroid is given little attention. In addition, it scares away its high cost. Another disadvantage for many is the fact that this method of taking the drug is not effective because of the non-alkylation of methenolone by 17-alpha. It seems that the 1-methyl group is able to protect it to a certain level from the effects of metabolism to 1- or 2-hydroxymetabolite. But even if this is true, then acetate does not show enough oral biological activity, therefore, in order to achieve a good effect, it is necessary to take fairly large doses of the drug.

This steroid is not aromatized because it is a derivative of dihydrotestosterone. In addition, it is not too strongly progestational active. Thus, primobolan most likely exhibits properties inherent in the aromatase inhibitor because of what is, in fact, a derivative of dihydrotestosterone. This property fixed the reputation of the steroid as a “dry heiner” behind Primobolan, which has an absolutely insignificant depressing property. Taking into account that methenolone is initially reduced by 5-alpha, then this enzyme does not metabolize it later. However, it is worth remembering that this steroid can be metabolized directly in skeletal muscles under the influence of 3-alpha hydroxysteroid dehydrogenase. But this metabolism occurs significantly less strongly than DHT. As a result of such influences, a weaker ratio of androgenic and anabolic activity can be observed in its weaker molecule. Also, methenolone does not bind too strongly to a substance such as globulin, which binds the sex hormone. Also, there is no conclusive evidence that methenolone enters at least a slight interaction with the receptors of progesterone or a glucocorticoid. So, Primobolan is not very conducive to weight gain, but this effect is due to the fact that fat and water in the body do not stay for long. The difference between primobolan is that it is used when trying to gain a quality mass, but at the same time to receive a small number of negative side effects, or not to receive them at all. But thus, it is much more preferable to use this preparation by injection. In the case of using this drug in small quantities women, it is even possible to avoid the most minor side effects. According to some researchers, taking primobolana in limited amounts does not even affect the cessation of the body’s production of natural testosterone. And its insignificant influence on the decrease in testosterone production is due to the fact that it does not pass into estrogen. But, nevertheless, such suppression may well increase along with an increase in the amount of the drug taken. Few people know that methenolone, like oxymetholone, promotes an increase in the body’s quantity of red blood cells. However, methenolone in any form, even in tablets, though in injections, has never been so widespread and accessible as the rest of the “reserve”. Moreover, what appears on the market is worth considerable sums and is not available to everyone. Methenolone is a product that only a limited number of producers produce and it is a deficit not only in free sale, but also in the black market.

Enanthate methenolona is an injection form of this drug, which is known in the market under the name Primobolan Depot. Ether enanthate has the ability to slowly dissolve tissues, which allows you to enter it into the body no more than once every two weeks. But many increase the frequency of its reception in two to four times, using a steroid a couple of times a week. If you use methenolone by injection, the effect will be much stronger than the oral form of the drug. This is due to the fact that injections are not subject to the property of metabolism of the first pass. And with him it is always necessary to fight. If the evaporation is carried out, the ether will turn into a substance, which is the basis for methenolone.

In the form of injections, the enanthate ester together with methenolone is a fairly strong steroid. The dosage of this drug is up to 100 ml. A week for women and up to 600 ml. – for men. In order to avoid the appearance of androgenic effect, women should not use the drug more often than once in 10 days, and best of all – even less. In general, methenolone is by far one of the safest steroids on the market. Despite the fact that methenolone is not alkylated by C-17, the 1-methyl group can cause increased levels of enzyme in the liver, even if the drug is injected. However, this effect is much less than during the administration of methandrostenolone and other C-17 acryl derivatives. Of course, this steroid does not belong to the category of drugs that make it possible to obtain a lightning effect. This is due to the fact that it delays water and does not have the same capacity as similar drugs that are injected into the body, for example, the same testosterone or nandrolone. But the methenolone has its fans and devotees, because, despite the lack of quick feedback, it also lacks significant side effects caused by taking other steroids.

Effect of Stanozolol

Stanozolol is a highly modified version of dihydrotestosterone, a synthetic one. Initially, this drug was released on the market called Winstrol. In it, in the traditional and familiar structure of steroids with the presence of the A-ring, an additional system of rings was added. Stenozolone has rather weak binding abilities, as it does not bind well enough to the androgen receptor. But the period of his half-life, which lasts nine hours, can be considered quite long, as for this steroid. And this is also one of the factors that led to its low binding ability. This steroid can not be converted into a metabolite of estrogen by the procedure of aromatization, besides, it is already reduced to 5-alpha. Therefore, further reduction is not possible. But at the same time it has a small capacity for anti-aromatism. Also, Stanozolol is very poorly associated with the SGHG – globulin, which binds the sex hormone. Because of this, in the overwhelming majority of cases, it is in a free state. Although directly interacting with the glucocorticoid receptors, Stanozolol does not interact, it can enter into a reaction with the protein STBP, which binds the glucocorticoid. As a result, the bound cortisol is pushed out and begins to circulate freely. At the same time, there is scientifically confirmed data that stanozolol exerts its influence and releases cortisol from the suprarenals. As a result, his level goes down, especially if you take this medication on an ongoing basis. If you stop taking a steroid, you can get a “ricochet” effect, as a result of which the production of cortisol by the body increases dramatically. Among other things, taking the drug can cause severe pain in all joints.

Despite the fact that stanozolol exhibits a fairly large ratio of androgenic and anabolic activity, it appears to apply to androgens. And its antiglucocorticoid properties increase the anabolicity index due to the binding of androgen receptors. Another effect of Stanozolol is its ability to lower the presence of thyroxine-binding globulin in the body. But, at the same time, not as much as it happens during the intake of other steroids of the anabolic-androgenic group.

Stanozolol can be taken in tablets or injected. Due to lack of etherification, this steroid should be taken every day. Some manufacturers produce injectable stanozolol with fairly large crystals, so often a large diameter needle is needed to ensure a smooth injection procedure. Also, stanozolol is considered insufficiently effective, despite a good ratio of anabolic to androgenic activity. But this is because it does not have the property of accumulating water in the body.