Primobolan depot – combined drug whose action is determined by the components included in its composition.Aspirin has analgesic, antipyretic, anti-inflammatory effects associated with inhibition of cyclooxygenase 1 and 2, regulate the synthesis of prostaglandins;inhibits platelet aggregation. Caffeine enhances the reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates blood vessels of skeletal muscle, brain, heart, kidneys, reduces platelet aggregation; It reduces drowsiness, fatigue, enhances mental and physical performance. Paracetamol has antipyretic, analgesic effect.
Indications for use
primobolan depot is used in adults with moderately or weakly expressed pain syndrome (headache, toothache, neuralgia, myalgia, chest radicular syndrome, lumbago, arthralgia, tuberculosis, migraine), in adults and children over 15 years to reduce the high temperature body, with “colds” and other infectious and inflammatory diseases.
- Hypersensitivity to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) or xanthine; Hypersensitivity to other components of the drug;
- erosive and ulcerative lesions of the gastrointestinal tract (exacerbation), gastrointestinal bleeding;
- expressed human liver or kidney;
- asthma induced by intake of acetylsalicylic acid, salicylates and other nonsteroidal anti-inflammatory drugs;
- hemorrhagic diathesis (von Willebrand disease, hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);
- dissecting aortic aneurysm;
- deficiency of glucose-6-phosphate dehydrogenase;
- portal hypertension, vitamin K deficiency;
- irritability, sleep disturbances, anxiety disorders (agoraphobia, panic disorder);
- organic diseases of the cardiovascular system (acute myocardial infarction, severe coronary heart disease, hypertension), paroxysmal tachycardia, frequent ventricular premature beats;
- surgery, accompanied by bleeding;
- children under 15 years.
Pregnancy and lactation
Contraindicated use during pregnancy in the I and III trimester, the second trimester of pregnancy is possible one-time taking the drug at the recommended doses only if the expected benefit to the mother will not exceed the potential risk to the fetus.
If necessary, use during lactation should stop breastfeeding.
Be wary – hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer (in history), heart failure, severe.
Dosing and Administration
The drug is administered orally after meals 1-2 tablets 2-3 times a day. The maximum daily dose – 6 tablets. The interval between doses of the drug should be at least 4 hours. To reduce the irritant effect on the gastrointestinal tract, the drug should be taken after meals, drinking water, milk, alkaline mineral water.
If the kidney or liver function a break between meals – not less than 6 hours. The drug should not take more than 5 days in the appointment as an analgesic, and more than 3 days as antipyretic. Other dosage and application of the scheme establishes a physician.
Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, the gastro-intestinal bleeding, liver and / or kidney failure, increased blood pressure, tachycardia.
Allergic reactions: skin rash, angioedema, bronchoconstriction.
Chronic administration – dizziness, headache, blurred vision, tinnitus, decrease platelet aggregation, anticoagulation, haemorrhagic syndrome (epistaxis, gingival bleeding, purpura, and others.), kidney disease with papillary necrosis; deafness; Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), Reye’s syndrome in children (metabolic acidosis, disorders of the nervous system and psyche, vomiting, abnormal liver function).
Nausea, vomiting, stomach pain, sweating, pale skin, tachycardia. When light intoxication – ringing in the ears; severe intoxication – drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding. As the intoxication – progressive paralysis and respiratory uncoupling of oxidative phosphorylation, causing respiratory acidosis. If you suspect a poisoning should immediately seek medical help. Treatment: The victim should be gastric lavage and appoint adsorbents (activated charcoal).
Interactions with other drugs
increases the effects of heparin, indirect anticoagulants, reserpine, steroid hormones, and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, protivopodagricakih funds, promote excretion of uric acid.
Increases side effects of glucocorticoids, sulfonylureas, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.
You should avoid the drug combination with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcoholic beverages (increases the risk of hepatotoxic effect).
Under the influence of paracetamol during removal of chloramphenicol increases 5 times. Caffeine accelerates the absorption of ergotamine.
Salicylamide, and others. Stimulants microsomal oxidation contribute to the formation of toxic metabolites of paracetamol, affecting the function of the liver. Metoclopramide accelerates the absorption of paracetamol. If readmission paracetamol may enhance the effect of anticoagulants (bishydroxycoumarin).
Prolonged use of the drug requires monitoring of peripheral blood and functional state of the liver. Since acetylsalicylic acid has antiagregatnoe action, the patient, if he is to surgery, doctor should be forewarned of taking the drug. Aspirin in low doses reduces the excretion of uric acid. This may in some cases to provoke an attack of gout.
During treatment should abandon the use of alcoholic beverages (increased risk of gastrointestinal bleeding).
Aspirin has a teratogenic effect: when used in I trimester of pregnancy results in congenital malformations – the splitting of the upper sky; in the III trimester – contributes to the inhibition of labor (inhibition of prostaglandin synthesis), closure of the ductus arteriosus in the fetus, causing pulmonary vascular hyperplasia and hypertension in the blood vessels of the pulmonary circulation. Aspirin is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets.
The drug is not prescribed as a pain medication to persons under 18 years of age, as antipyretic – children up to 15 years with acute respiratory diseases caused by viral infections iz at risk of developing Reye syndrome (encephalopathy and acute fatty liver with development of acute liver failure). where to find anabolic steroids steroid sources uk where to buy steroid cream